ABSTRACT
Background: platelets contain a significant amount of growth factors that have positive effects on local tissue repair and endometrial receptivity
Case: here we present a 45-yr-old woman with primary infertility and two failed in vitro fertilization [IVF] cycles who was candidate to receive donor eggs. Five consecutive frozen-thawed embryo transfer cycles with good quality embryos were performed within 2 yr. With the diagnosis of recurrent implantation failure [RIF], the patient was treated for improving endometrial receptivity with intrauterine administration of autologous platelet-rich plasma [PRP], 24 hr before embryo transfer. The patient gave birth to a healthy baby boy weighing 2350 gr in the cesarean section
Conclusion: extensive literature search suggests that this is the ?rst successful pregnancy after administration of PRP in a woman with RIF. Local administration of PRP before embryo transfer may play a vital role in successful implantation
ABSTRACT
Women with polycystic ovary syndrome [PCOS] are at increased risk for cardiovascular [CV] and metabolic disorders. There is a close relationship between elevated androgen plasma levels and the ultrasound findings of stromal hypertrophy. In randomized trials, the administration of metformin has been shown to be followed by an improvement in insulin sensitivity and decrease in androgen levels in most women. In the present study, we investigate the association between reduced ovarian volume in PCOS patients after administration of metformin with improvement in CV risk factors. This was a randomized clinical trial study. A total of 28 women diagnosed with PCOS who referred to the infertility clinic were selected. Anthropometric characteristics of the patients, mean ovarian volume and plasma levels of fasting blood sugar [FBS], lipid profile, luteinizing hormone [LH], follicle stimulating hormone [FSH], estradiol, testosterone, 17-alpha-OH progesterone [17OHP], dehydroepiandrosterone sulfate [DHEAS], C-reactive protein [CRP] and homocysteine [Hcy] were evaluated before and after treatment with 500 mg metformin, three times daily for three months. Statistics were calculated with the aid of SPSS 16.0 with student's paired t-and Pearson's correlation coefficient tests. Significance was set at p<0.05. There were significant reductions in mean ovarian volume and body mass index [BMI], in addition to CRP, Hcy, testosterone, FBS, HDL and LDL levels. There was a positive correlation between mean ovarian volume and waist-to-hip ratio [WHR]. After treatment, there correlation noted with reduction in mean ovarian volume and decreased BMI, in addition to reductions in CRP, LDL, Hcy and testosterone levels. A positive correlation may exist between reduced mean ovarian volume and improvement in CV risk factors after administration of metformin [Registeration Number: IRCT138903244176N1]